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TDR Disease Reference Group on Chagas Disease, Human African Trypanosomiasis and Leishmaniasis
Research priorities for Chagas disease, human African trypanosomiasis and leishmaniasis : technical report of the TDR Disease Reference Group on Chagas Disease, Human African Trypanosomiasis and Leishmaniasis
Alternate Title Research priorities for Chagas disease, HAT and leishmaniasis
Geneva, Switzerland : World Health Organization, c2012
book jacket
Location Call Number Status
 4th Floor  RA644.C26 T37 2012    AVAILABLE
Subject(s) Chagas' disease
Chagas' disease -- Diagnosis
Chagas' disease -- Prevention
Chagas' disease -- Transmission
African trypanosomiasis
African trypanosomiasis -- Diagnosis
African trypanosomiasis -- Prevention
African trypanosomiasis -- Transmission
Leishmaniasis
Leishmaniasis -- Diagnosis
Leishmaniasis -- Prevention
Leishmaniasis -- Transmission
Physical Description xii, 100 p. : maps ; 24 cm
Note "Technical report of the TDR Disease Reference Group on Chagas Disease, Human African Trypanosomiasis and Leishmaniasis"--t.p
Includes bibliographical references (p. 85-97)
Contents 1. Introduction -- 1.1 Reasons for setting research priorities -- 1.2 TDR stewardship mandate -- 1.3 Goal of this report /strategic objectives -- 1.4 Overview -- 2. Methodology and prioritization -- 2.1 Authoritative evidence review to define thematic areas -- 2.2 Stakeholders' consultation and second round of criteria-based ranking -- 2.3 Final round of ranking -- 3. Epidemiology and burden of disease -- 3.1 Chagas disease -- 3.2 Human African trypanosomiasis -- 3.3 Leishmaniasis -- 4. Clinical forms, pathogenesis and HIV coinfection -- 4.1 Chagas disease -- 4.1.1 Clinical presentations -- 4.1.2 Chagas heart disease -- 4.1.3 Gastrointestinal manifestations -- 4.1.4 Congenital Chagas disease -- 4.1.5 Chagas disease and HIV coinfection -- 4.2 Human African trypanosomiasis -- 4.2.1 Pathogenesis -- 4.2.2 Clinical presentation -- 4.3 Leishmaniasis -- 4.3.1 Clinical presentations -- 5. Diagnosis -- 5.1 Chagas disease -- 5.1.1 Parasitological diagnosis -- 5.1.2 Serology -- 5.1.3 Quantitative and qualitative detection of parasite DNA -- 5.1.4 Diagnosis in newborns -- 5.1.5 Diagnosis of therapy efficacy and cure -- 5.1.6 Diagnosis of drug resistant Chagas disease -- 5.2 Human African trypanosomiasis -- 5.2.1 Demonstration of parasite -- 5.2.2 Serology -- 5.2.3 Quantitative and qualitative detection of parasite DNA -- 5.2.4 Staging of the disease -- 5.3 Leishmaniasis -- 5.3.1 Parasitological diagnosis -- 5.3.2 Serology -- 5.3.3 Detection of parasite products -- 5.3.4 Quantitative and qualitative detection of parasite DNA -- 6. Drugs and drug resistance -- 6.1 Current treatment and development of new drugs -- 6.1.1 Chagas disease -- 6.1.2 Human African trypanosomiasis -- 6.1.3 Leishmaniasis -- 7. Vaccines against Chagas disease, human African trypanosomiasis and leishmaniasis -- 7.1 Overview -- 7.2 Chagas disease -- 7.3 Human African trypanosomiasis -- 7.4 Leishmaniasis -- 8. Vector control -- 8.1 Chagas disease: triatomine bug control -- 8.2 Human African trypanosomiasis: tsetse fly control -- 8.2.1 Tsetse species of highest priority -- 8.2.2 Control activities at all levels -- 8.2.3 Costs of vector control -- 8.3 Leishmaniasis: sandfly control -- 8.3.1 Source reduction -- 8.3.2 Targeting sugar-feeding adult sandflies -- 8.3.3 Extermination of sandflies feeding on domestic animals -- 8.3.4 Flight barriers for preventing sandflies from reaching houses -- 8.3.5 Protection of homes--indoor residual insecticide spraying -- 8.3.6 Protection of rooms/porches--insecticide diffusers and coils -- 8.3.7 Personal protection--insecticide-treated nets and repellents -- 8.3.8 Integrated disease-control campaigns -- 9. Economic evaluation of health-care interventions -- 10. Research priority recommendations
Summary "This report provides a review and analysis of the research landscape for three diseases--Chagas disease, human African Trypanosomiasis and leishmaniasis--that dispropotionally afflict poor and remote populations with limited access to health services. It represents the work of the disease reference group on Chagas Disease, human African Trypanosomiasis, and leishmaniasis (DRG3) which was established to identify key research priorities through review of research evidence and input from stakeholders' consultations. The diseases, which are caused by related protozoan parasites, are described in terms of their epidemiology and disease burden, clinical forms and pathogenesis, HIV coinfection, diagnosis, drugs and drug resistance, vaccines, vector control, and health-care interventions. Priority areas for research are identified based on criteria such as public health relevance, benefit and impact on poor populations and equity, and feasibility. The priorities are found in the areas of diagnostics, drugs, vector control, asymptomatic infection, economic analysis of treatment and vector control methods, and in some specific issues such as surveillance methods or transmission-blocking vaccines for particular diseases. This report will be useful to researchers, policy and decision makers, funding bodies, implementation organizations, and civil society."--P. 4 of cover
Note Also available online
Series Technical report series (World Health Organization) ; 975
Alternate Author World Health Organization

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